Mr. Hell mutilated Dr. Karl Matthews at a government laboratory, where biological weapons were secretly being developed. The doctor's precocious daughter, Tyler, who discovered her fathers body with his eyes missing, was then pursued by Harry through the lab's subterranean tunnels. During the chase, Harry was accidentally destroyed by toxic industrial acid, and his remains flowed into a storage container. Was this the end for Mr. Hell?

Fourteen years later, we find a grown-up Tyler, now a security guard at the lab, which is soon scheduled for demolition. During the lab's closing process, incompetent waste removal workers unwittingly release Harrys toxic essence. Mr. Hell is back, and on the hunt! Complicating matters, a group of mercenaries led by Dominique Horney (Tracy Scoggins) invade the laboratory to steal a hidden vial of deadly bacterium to sell to terrorists. This small private army may be prepared for a few security guards, but not for Mr. Hell! As for Tyler, will she survive the band of professional killers and defeat, once again, the diabolical butcher, Mr. Hell?!